Top 16 Cool and Unique Hotels in St. Louis 2023

Situated on the banks of the Mississippi and Missouri Rivers, the city of St. Louis is often called the Gateway to the West and is filled with plenty of trails, parks, and world-class attractions. Tt was also listed as one of the “Hottest Hipster Markets in America” (by and its many awesome places to stay also reflect this trendy vibe. From quirky boutiques to designer spots perfect for Instagrammers, here are my favorite cool and unique hotels in St. Louis, Missouri…  

Best For Instagrammable Decor

Angad Arts Hotel

Design hotel in St Louis

Cool hotel in St Louis

Boutique hotel in St Louis

At Angard Arts Hotel, just a stone’s throw from the Gateway Arch, I was submerged in a realm bursting with color and creativity. The ambiance—soothing, refreshing, and motivational—highlighted locally curated art pieces throughout the space. The bedrooms were uniquely themed, each pulsating with the vibrant energy of red, blue, green, or yellow.

What truly captivated me were the stunning permanent art installations adorning the rooms, elevating the experience further. The hotel’s commitment to art extended to regular exhibitions, a testament to the wealth of talent it housed.

The Commonwealth restaurant, highly recommended and rightfully so, indulged my palate with delectable modern European cuisine. The hotel’s offerings extended beyond food—an outdoor rooftop terrace, a skyline-view library, and a grand ballroom provided options for business engagements and celebratory events. This place seamlessly merges artistic inspiration with comfort and functionality.

One of my favorite aspects was the vibrant, themed bedrooms pulsating with colorful energy.


Ultra-chic unique design

Exotic skyline view

Fascinating art gallery

Dietary food options are available


No spa

It can be a little noisy

Best For Great Location

St. Louis Union Station Hotel

Unique hotel in St Louis

Themed hotel in St Louis

Nestled inside the iconic St. Louis Union Station, I found the St. Louis Union Station Hotel—an exquisite blend of classic charm and contemporary flair. The grandeur of the original architecture harmonized seamlessly with the modern luxuries, creating an experience that instantly became one of my favorites in the city’s heart.

Dining beneath the magnificent 65ft arches in the Grand Hall was a definite highlight. The added charm of a spectacular 3D light show made it an enchanting evening. This hotel was Situated near Downtown and was a perfect base for exploring the city. But what truly amazed me was the abundance of attractions right at my fingertips—the mix of retail outlets, event spaces, cozy cafes, tempting restaurants, and family-friendly entertainment within this historic station.

The hotel’s versatility was impressive, with multiple spaces available for events and gatherings. And the cherry on top was the outdoor pool and fitness center, adding that extra touch to an already exceptional stay.

Dining under the stunning arches in the Grand Hall was an enchanting highlight.


Vibrant and creative design

Proximity to great attractions

Minimarket on site

Mini-golf and golf course


No microwave in rooms

Parking is extra

Best For Gen Zs and Millennials

The Moonrise

The Moonrise Hotel in St. Louis

The Moonrise Hotel St Louis

At The Moonrise Hotel, I discovered an extraordinary rooftop garden where I enjoyed drinks beneath the world’s largest man-made moon. The fusion of sleek design with neon accents, futuristic memorabilia, and captivating artwork made it one of my favorite places.

The celebrity suites were a unique highlight, inspired by notable personalities from St. Louis. Exploring the range of event spaces, especially the Twilight room with breathtaking views through a glass solar panel roof, amazed me. Located on the Delmar Loop, I found myself near theaters, museums, restaurants, and parks. It indeed was an incredible experience, making it easily one of the most excellent hotels in St. Louis.

The rooftop garden, with drinks beneath the world’s largest man-made moon, was an extraordinary experience.


Glass solar panel roof

Stunning city views

Unique and sleek design

Free parking onsite


It can be slightly noisy

No swimming pool

Best For Unique Stay

21c Museum

21c Museum Hotel St Louis

21c Museum Hotel St Louis - an ultra-chic and epic award-winning boutique hotel2

21c Museum Hotel St Louis - an ultra-chic and epic award-winning boutique hotel

Staying at the newest spot in downtown St. Louis was a treat. Housed in a revamped 1920s YMCA, the 21c Museum Hotel felt like more than just a place to crash – it was an experience. Upon arrival in Spring 2023, I was greeted with luxury accommodations fused seamlessly with a contemporary art museum. The rooms were sleek and stylish, adorned with original artwork, plush seating, and heavenly bedding. The suites, a league of their own, boasted kitchenettes, cozy fireplaces, and breathtaking views of downtown St. Louis.

The wellness center was a haven. An indoor lap pool beckoned, accompanied by a sauna and a top-notch fitness studio. Ah, the dining choices! Idol Wolf, a Spanish-inspired restaurant, spoiled me with creative cocktails, while the Good Press coffee shop, a gem in the neighborhood, became my go-to spot.

This place isn’t just a hotel; it’s the doorway to St. Louis’ burgeoning art scene and beyond. Its prime location and innovative concept set the stage for a memorable stay and a gateway to much more.

The sleek rooms adorned with original artwork and the fantastic wellness center were standout features.


Unique art museum

Stunning downtown St. Louis scenery

Quality spa and wellness center

Elegant design of rooms


No parking

Not pet-friendly

Best For Historic Charm

The Last

Best hotels in St Louis

Trendy hotel in St Louis

Hip hotel in St Louis

While visiting the Washington Avenue Garment District, I discovered The Last Hotel St Louis, nestled in the historic International Shoe Co. Building. The moment I stepped inside, I was struck by the rich history woven into its design.

The interior decor was a blend of classic luxury, boasting rich browns, creams, and tan furniture complementing the original stone carvings, metalwork, and aged wooden features. The ambiance effortlessly merged Art Deco and Neoclassical styles, creating a captivating setting. Exploring its three floors, I found expansive meeting spaces – two ballrooms adorned with floor-to-ceiling windows and six well-appointed boardrooms. The views were breathtaking, allowing natural light to dance through the rooms.

Being so close to downtown St. Louis, I had endless options for exploration. However, indulging in the Italian-inspired kitchen was a highlight, and the rooftop bar and restaurant offered a delightful escape, especially with the poolside dining experience. The hotel’s amenities were impressive – from the well-equipped fitness center to the inviting game room.

Exploring the blend of classic luxury and Art Deco ambiance was captivating.


Italian-influenced cuisine

Heated outdoor swimming pool

Art Deco design

Pets are allowed


Parking is extra

No microwave in rooms

Best For Trendy Design

Live! by Loews

Luxury hotel in St Louis

Hipster hotel in St Louis

Modern hotel in St Louis

I adore this luxury hotel in Ballpark Village, next to St. Louis Cardinal’s Busch Stadium. As a sports enthusiast, it’s one of my favorite places, offering a vibrant hub for dining, drinking, and various events.

The incredible location isn’t the sole attraction; the rooms are flooded with natural light through expansive windows, giving a modern and sleek vibe. During my stay, I indulged in their fitness facility equipped with Pelotons, and the highlight was their exclusive whiskey aging room filled with rare finds and local favorites.

Beyond that, the hotel offers sophisticated event and meeting spaces, all with breathtaking views of downtown, Busch Stadium, and the iconic Gateway Arch. The cherry on top was the fantastic outdoor rooftop space, perfect for ceremonies, with a cool and spacious ambiance.

The whiskey aging room and the stunning rooftop space were memorable.


Modern design and decor

Proximity to Busch Stadium

Outdoor Swimming Pool

A fitness centre and a terrace


Pool is seasonal

No spa

Best For Pet-friendly Getaway

Hotel Indigo Downtown

Creative hotel in St Louis

Modern boutique hotel in St Louis

Funky design hotel in St Louis

At Hotel Indigo, I discovered a fantastic celebration of local cultures. From captivating artwork displaying regional talent to menus crafted with locally sourced ingredients, this boutique hotel embraces its surroundings.

The restaurant, Switch List, offered a delectable array of modern American dishes. But what truly enchanted me was the rooftop bar, where I indulged in handcrafted cocktails and savored locally brewed beers while soaking in mesmerizing sky-high city views.

Surrounded by the heart of downtown, I was immersed in genuine Midwestern hospitality just steps away from the hotel. And at day’s end, the spa-style bathrooms and luxurious bedrooms provided a cozy and stylish haven for unwinding. This place became one of my favorite spots to immerse myself in the local vibe while enjoying comfort and elegance.

The rooftop bar with mesmerizing city views and locally crafted cocktails was exceptional.


Unique design

Stunning room city view

Pets are allowed

Spa-style bathrooms


Some rooms are small

Parking is extra

Best For Scenic Views

The Chase Park Plaza Royal Sonesta

The Chase Park Plaza Royal Sonesta St. Louis

Upscale hotel in St Louis

The Chase Park Plaza Royal Sonesta St. Louis

At The Chase Park Plaza Royal Sonesta St. Louis, I was in an impressive Art Deco building that overlooks the lush Forest Park. The mix of old-world glamour and modern elegance is breathtaking. The ambiance blended sophisticated greys, blues, ivories, and rich, dark wood, beautifully complemented by natural light. It truly created a luxurious setting that I fell in love with instantly.

There’s no shortage of dining experiences here. I indulged in local beers and handcrafted cocktails at any of their four restaurants, each offering a mix of fine dining and traditional American fare. No matter the weather, I could relax outside thanks to the inviting outdoor fireplace and heated pool.

One of the highlights was the five-screen movie theatre showcasing the latest releases. It was the perfect way to unwind. Moreover, the hotel offers several meeting rooms and a stunning ballroom, making it an ideal event venue. It was a place that effortlessly combined relaxation, entertainment, and elegance.

The glamorous mix of old-world charm and modern elegance, especially the outdoor fireplace and pool, left a lasting impression.


Lavish ambiance

Eclectic architecture

Mediterranean-style pool

Pets friendly rooms with great views


Parking is extra

Some bathrooms need an upgrade

Best For Fun Vibe

Aloft Cortex

Aloft St. Louis Cortex - a cool, hip and vibrant hotel2

Aloft St. Louis Cortex - a cool, hip and vibrant hotel Aloft St. Louis Cortex - a cool, hip and vibrant hotel1

While staying at Aloft in St. Louis, I found myself in the vibrant heart of the Cortex Innovation Community. Surrounded by universities, tech startups, and an array of attractions like the Gateway Arch and Busch Stadium, the location was unbeatable. The rooms, with their sleek decor and pops of vibrant color, felt welcoming. Streaming services on large TVs added a modern touch to relaxation.

The WXYZ bar was a favorite spot, offering cocktails and a lively atmosphere with happy hour specials and live music. I used the swimming pool and fitness center to recharge between outings. And when it came to dining, Wasabi Sushi stole the show with its lunch and dinner offerings. The cooked-to-order breakfast each morning was a delightful start to my days there.

The vibrant Cortex location and the WXYZ bar’s lively atmosphere were delightful.


The sleek interior decor of rooms

Wasabi Sushi Restaurant onsite

Vibrant ambiance

Pets are allowed


Some rooms are small

No parking

Vibe might not be for everyone

Best For Boutique Style


Magnolia Hotel St. Louis, a Tribute Portfolio Hotel - an elegant and classic hotel1

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel - an elegant and classic hotel Magnolia Hotel St. Louis, a Tribute Portfolio Hotel - an elegant and classic hotel2

At the Magnolia Hotel, I entered a world crafted by Cary Grant and his friends – a place brimming with timeless elegance, crystal chandeliers, and delightful “chocolates on the pillow.” The entire decor, mirroring the hotel’s namesake flower, embraced shades of cream, accentuated by glistening crystal and hints of gold. Every corner exuded luxury, from the lavish drapes to the opulent furnishings and headboards.

During my stay, I indulged in the allure of the meticulously preserved 1924 building by opting for the Cary Grant or Presidential suites, exuding Old Hollywood-style glamour coupled with modern comforts. The hotel offered conveniences like a fitness center and valet parking, adding to the overall experience.

A highlight was the signature Robie’s restaurant, where I savored classic dishes and cocktails, including the famed Cary Grant’s Night Cap!, available through impeccable room service. Situated in downtown St. Louis, the hotel placed me right at the city’s pulse – surrounded by vibrant nightlife, diverse dining options, and key attractions like the America’s Center, Busch Stadium, and the iconic Gateway Arch.

The timeless elegance and the opulent suites, along with the Cary Grant-inspired restaurant, were highlights.


Decor in various cream tones

Minimarket on site

Pets are allowed

Meeting/banquet facilities available


No parking

Elevators are a little small

No spa

Best For Luxury

The Four Seasons

Hip and trendy hotel in St Louis

Luxury hotel in St Louis

At The Four Seasons, St. Louis, I’m enveloped in a serene, lavish setting, the airy spaces and elegant design soothing my senses. The abundance of floor-to-ceiling windows adds to the tranquility. My visit is all about unwinding. The spa, a haven designed for relaxation, spoils me with cutting-edge treatments. The outdoor pool, nestled by private cabanas, invites pure indulgence.

Up on the rooftop bar, I’m treated to breathtaking city vistas. The Cinder House restaurant, with its wood-fired culinary inspirations from around the world, captivates my palate through the expertise of top chefs. Nestled close to the riverfront, this haven goes beyond. A virtual golfing suite beckons and access to Lumiere Place and the casino ensures non-stop entertainment. It’s an oasis of leisure and excitement all in one.

The serene spa facilities and the rooftop bar with breathtaking vistas created a perfect ambiance.


Marvelous spa facilities on-site

Live music/performance

Ultra-modern decor and ambiance

Outdoor heated swimming pool


Parking is extra

Not for the budget-friendly crowd

Best For Partying

HoteLumiere at The Arch

Fun party hotel in St Louis

Funky hotel in St Louis

Modern hotel in St Louis

I explored Lumiere Place, nestled in downtown St. Louis. The hotel brims with entertainment—diverse restaurants offering global and local cuisines, a bustling casino adorned with slot machines, table games, and a vibrant poker room. My evenings were lively at the sports bar, surrounded by numerous screens, while daytime swims at the indoor pool and workouts at the fitness center kept me energized. The expansive patio illuminated the nights, adding to the enchantment.

What captivated me was the endless fun within downtown St. Louis itself. Yet, amidst the excitement, the rooms offered a plush, comforting haven, many boasting exceptional city views. It was a delightful balance of vivaciousness and relaxation.

The diverse entertainment options and plush rooms with exceptional city views were fantastic.


Free parking onsite

Stunning scenery

Various casino games

ATM/cash machine on site


Some bathrooms are small

No microwave in rooms

Best For Spa and Wellness

Hotel Saint Louis

Hotel Saint Louis, Autograph Collection 

Luxury hotel in Saint Louis

The city center hotel I stayed at had a calming atmosphere with its classic décor. Neutral tones mixed with gold and dark blues set the mood perfectly. At Hotel Saint Louis, relaxation options were aplenty. I loved taking a dip in the outdoor pool and indulging in treatments at their full-service spa. Gazing at the St. Louis skyline from the rooftop bar was a favorite pastime, as was dining on American hometown favorites at Union 30. The restaurant’s panoramic windows offered fantastic views.

The location of the hotel, nestled between America’s Center Convention Complex and Ballpark Village, was ideal for business and leisure travelers. The grand ballroom was adorned with chandeliers, and the multiple meeting rooms were versatile for various events.

The classic decor, outdoor pool, and rooftop bar offering stunning skyline views were relaxing.


Outstanding spa/wellness packages

Retro decor

Spectacular St. Louis skyline view


Parking is extra

Balconies are somewhat small

Best For Themed Design

The Cheshire

Unique boutique hotel in St Louis

Themed hotel in St Louis

I stepped into The Cheshire, a luxury boutique hotel oozing Brit-inspired charm. Its Tudor-style exterior mirrored an old English manor house, instantly immersing me in a classic English tale.

Exploring the rooms, I discovered they were named and designed after famed British writers, their works echoing through the exquisite decor. Antique furnishings adorned the space, blending seamlessly with modern amenities. I found relaxation by the poolside and kept active at the fitness center. For gatherings, the Boundary, a versatile space, proved perfect. The dining options were a delight. The English-style Fox and Hounds exuded classic charm, while the sleek Italian Gastropub offered a modern twist. Alternatively, the city center boasted numerous nearby restaurants, spoiling me for choice.

Exploring the themed rooms named after British writers and the diverse dining options were fascinating.


Tudor-esque exterior and interior

Retro decor

Interconnected rooms are available

Parking available onsite


It can be a little noisy

Breakfast options are limited

Best For Gardens and Shrubbery

Seven Gables Inn

Seven Gables Inn, St Louis West, a Tribute Portfolio Hotel - a cozy and charming hotel Seven Gables Inn, St Louis West, a Tribute Portfolio Hotel - a cozy and charming hotel2

I loved my stay at the charming Tudor Revival building from 1926. Its half-timber exterior and modern rooms blended comfort and tradition seamlessly. Set in Clayton, it was perfectly located near business spots and unique shops, galleries, and restaurants, just a short drive from downtown St. Louis.

My room was spacious, boasting luxury linens, a TV, a fridge, and a coffee maker. A delightful breakfast spread awaited each morning, with fresh fruits adding that extra touch. The Seven American Bistro offered a diverse and mouthwatering menu for lunch and dinner. Live music in the lobby created a fantastic atmosphere, and I adored the seasonal outdoor seating in the terrace garden and the front patio. It was a truly enchanting experience.

The Tudor Revival building’s charm and the seasonal outdoor seating in the terrace garden were enchanting.


Eclectic Architecture

Entertainment staff

Outdoor fireplace


No parking

No gym or fitness center

Best For Great Breakfast

Casa Magnolia B&B

Quirky accommodation in St Louis

Historic guest house St Louis

At Casa Magnolia B&B, within steps of Missouri Botanical Gardens, I found a cozy red brick haven. The personal touch made my St. Louis trip unforgettable. They have three distinct double rooms, each with a private bath. Breakfast, a homemade delight, was served fresh or packed to-go – just like home.

Their garden, a seasonal outdoor pool, and a communal lounge added to the charm. I love this place for its warmth and homely feel.

The cozy red brick haven with personal touches and homemade breakfast made it feel like home.


Unique warm ambiance

Outdoor fireplace

Full gastronome breakfast options

Allergy-free rooms available


No spa

No gym or fitness center

Decor might not suit everyone

Comparison of Best Hotels in St. Louis

We at Global Grasshopper have compared the Top 16 Cool and Unique Hotels in St. Louis in the following table. 

Hotel NameLocationPrice Range (per night)Fitness FacilitiesDistance to Attractions (km)Nearby Restaurants
Angad Arts Hotel3550 Samuel Shepard Drive$152-$712No2.43
St. Louis Union Station Hotel1820 Market Street$225-$384No1.53
The Moonrise6177 Delmar in The Loop$308-$395No1.63
21c Museum1528 Locust street,$227-$332Yes1.33
The Last1501 Washington Avenue$233-$700Yes0.803
Live! by Loews799 Clark Street$225-$272Yes0.753
Hotel Indigo Downtown501 Olive St. Louis$114-$149Yes1.33
The Chase Park Plaza Royal Sonesta212 North Kingshighway Boulevard$453-$652No1.83
Aloft Cortex4245 Duncan Avenue$198-$221Yes1.93
Magnolia421 North 8th Street$200-$320No.553
The Four Seasons999 North 2nd Street$573-$830Yes0.953
HoteLumiere at The Arch901 North First Street$338-$373No0.903
Hotel Saint Louis705 Olive Street,$249-$296Yes0.553
The Cheshire6300 Clayton Road$152-$182No2.13
Seven Gables Inn26 North Meramec$232-$290No4.13
Casa Magnolia B&B4171 Magnolia Avenue$196No2.63

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